Bits: Inverse vaccine invented; Paxton acquitted; Quiet genocide in China

SciTechDaily reports about what appears to be a major advance in treating some very nasty autoimmune diseases: 

New Vaccine Can Completely Reverse Autoimmune Diseases 

Like Multiple Sclerosis, Type 1 Diabetes, and Crohn’s Disease

Researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) have developed a novel vaccine that, in laboratory tests, can completely reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and Crohn’s disease — all without shutting down the rest of the immune system.

A typical vaccine teaches the human immune system to recognize a virus or bacteria as an enemy that should be attacked. The new “inverse vaccine” does just the opposite: it removes the immune system’s memory of one molecule. While such immune memory erasure would be unwanted for infectious diseases, it can stop autoimmune reactions like those seen in multiple sclerosis, type I diabetes, rheumatoid arthritis, or Crohn’s disease, in which the immune system attacks a person’s healthy tissues.  

The inverse vaccine, described in a recent paper published in Nature Biomedical Engineering, takes advantage of how the liver naturally marks molecules from broken-down cells with “do not attack” flags to prevent autoimmune reactions to cells that die by natural processes. PME researchers coupled an antigen — a molecule being attacked by the immune system— with a molecule resembling a fragment of an aged cell that the liver would recognize as friend, rather than foe. The team showed how the vaccine could successfully stop the autoimmune reaction associated with a multiple-sclerosis-like disease.  

The job of the immune system’s T cells is to recognize unwanted cells and molecules — from viruses and bacteria to cancers — as foreign to the body and get rid of them. Once T cells launch an initial attack against an antigen, they retain a memory of the invader to eliminate it more quickly in the future. 

T cells can make mistakes, however, and recognize healthy cells as foreign. In people with Crohn’s disease, for instance, the immune system attacks cells of the small intestine; in those with multiple sclerosis, T cells mount an attack against myelin, the protective coating around nerves.

Hubbell and his colleagues knew that the body has a mechanism for ensuring that immune reactions don’t occur in response to every damaged cell in the body— a phenomenon known as peripheral immune tolerance and carried out in the liver. They discovered in recent years that tagging molecules with a sugar known as N-acetylgalactosamine (pGal) could mimic this process, sending the molecules to the liver where tolerance to them develops.  

More work is needed to study Hubbell’s pGal compounds in humans, but initial phase I safety trials have already been carried out in people with celiac disease, an autoimmune disease that is associated with eating wheat, barley, and rye, and phase I safety trials are underway in multiple sclerosis.

This has the feel of a major advance in dealing with autoimmune diseases. If this advances to later stage phase II and III human clinical trials, that would mark a major step toward developing an actual human vaccine. Phase I clinical trials are designed to assess safety. Phase II and III are to confirm safety and prove efficacy. This is research worth keeping an eye on.

The published Nature paper is here, but it's behind a paywall.

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The Texas Senate acquitted Ken Paxton after a 9 day trial. Paxton is a terribly corrupt politician, but it now appears he is the face the deeply corrupt, authoritarian radical right GOP. The Hill commented:

A University of Texas/Texas Politics Project poll released earlier this month found 24 percent of the Republicans who were asked if “Ken Paxton took actions while Attorney General that justify removing him from elected office” said he did, 32 percent said he didn’t, and 43 percent said they “didn’t know” or had “no opinion.”

At least in Texas, authoritarian, pro-corruption rot has infected the rank and file to the point there's not much difference between the R&F and the elites. For the authoritarian radical right Republican Party, the rule of law has fallen. 

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A NYT opinion describes China's quiet genocide:

The One Million Tibetan Children in China’s Boarding Schools

One day in late November 2016, back home in Tibet, I received a distressing call from my brother telling me I needed to check on his granddaughters. “Something very strange is happening,” he said.

My young relatives, who were 4 and 5 years old at the time, had just enrolled in a boarding preschool that the Chinese government had established in my hometown, Kanlho, a seminomadic region in the northeast corner of the Tibetan plateau.

Though it had only been three months since the girls had started at the school, my brother described how they were already beginning to distance themselves from their Tibetan identity. On weekends, when they could return from school to their family, they rejected the food at home. They became less interested in our Buddhist traditions and spoke Tibetan less frequently. Most alarmingly, they were growing emotionally estranged from our family. “I might lose them if something isn’t done,” my brother worried.

Concerned, I set out to the girls’ school a few days later to pick them up for the weekend. When they walked out of the gates, they waved to me but barely spoke. When we arrived home, the girls didn’t hug their parents. They spoke only Mandarin to each other and remained silent during our family dinner. They had become strangers in their own home.

After listening to the girls’ stories, I asked my brother what would happen if he just refused to send them. He teared up. Disobeying the new policy would mean having his name blacklisted from government benefits. Others who have protested the new schools have suffered terrible consequences, he said.

Over the course of my three years of fieldwork and meetings with students, parents and teachers, what I discovered was worse than anything I could have imagined.

I met young Tibetan children who could no longer speak their native tongue. The schools strictly controlled parental visits. In some cases, schoolchildren saw their families only once every six months. Dormitories, playgrounds and teachers’ offices were heavily surveilled.

What the Chinese dictators are doing in China to cultural and social diversity is what the American Christian nationalism wealth and power movement is starting to do in America now that it has the power to do so.